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Molecular diagnosis and management of hereditary breast and ovarian cancer syndrome: what’s new?
Hereditary breast and ovarian cancer syndrome has long been recognized as a high-risk for breast, ovarian, and/or fallopian tube cancer in women, while the phenotype of gynecologic disease caused by BRCA1/2 mutations is highly variable. Recent major advances in the genetic screening of patients with hereditary breast and ovarian cancer syndrome have led to improved molecular diagnosis and therapeutic management strategies. Here, we review the advances in molecular diagnosis and management of hereditary breast and ovarian cancer syndrome, with a focus on the BRCA1/2 mutation screening test.With imminent advances in medical procedures performed by minimally invasive techniques, there is a need to develop a variety of devices and medical instruments for the delivery of drugs to interior regions of the human body, including blood vessels, the heart, the digestive system, and the urinary tract. In the vasculature, for example, drug eluting stents (DES) have been found to be highly effective at preventing restenosis. The selection of a coating material that is compatible with body tissues, but which ultimately degrades upon exposure to various bodily fluids is key to successful application of this technology in an actual medical setting. Biodegradable materials are highly desirable for use as coatings on DES.
Poly-D,L-lactic acid is currently the most widely used biodegradable plastic in the medical device industry. The major drawback to this type of material is that it is anhydrous and brittle at room temperature, and has poor solubility in common organic solvents.
There is a need for biodegradable polymeric materials that have good processibility properties (such as melt flowability and extrudability) and good mechanical properties, e.g., sufficient toughness to allow them to be formed into films, coatings, and other complex shapes, as well as sufficient flexibility for them to be used in medical devices that are capable of being flexed, bent, or twisted when used. The materials should also be capable of being tailored to a particular use, e.g., in the medical area, by varying the composition of the polymers so that the properties, such

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